As results for the big phase 3 trials for the BNT-Pfizer and Moderna were looming, a debate ramped up: when would the…
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Bias The Pioneering Crossover Trials for Covid Vaccines and What We’ll Find OutRead more
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Bias Radical Vaccine Trial Transparency & Press Release Readouts: What’s the Problem?Read more
Every time a drug company press release of vaccine trial results blasts through the media, it’s followed by criticism of “science by…
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Bias Clinical Trials Are Vital for the Rest Of Us. Are They a Good Deal for the Participants?Read more
“People on a trial tend to do better”. Ordinarily, when I see someone make that point, I agree. But last week, when…
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Bias Let’s Be Serious About Bias in Protocols of Systematic ReviewsRead more
A detailed pre-specified protocol is supposed to be the superpower of a systematic review: its contents literally put the “systematic” into review…
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Bias A Cartoon Guide to Conflict of Interest Claims, Fair & FoulRead more
Claims of conflicts of interest have been one of the – let’s call it interesting – parts of being in debates…
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Bias The Renewed Debate About Blinding in Clinical TrialsRead more
Things can go really off the rails in clinical trials. Take the most influential trial of the Mediterranean diet…
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Bias Open Badges Redux: A Few Years On, How’s the Evidence Looking?Read more
A couple of years ago, I took shots at the way a small, uncontrolled study from 2016 of badges to encourage…
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Bias Is Gender Bias the Elephant in the “Endangered Physician-Scientist” Room?Read more
This, in 2008: Women make up an ever-increasing fraction of the students who train to become biomedical scientists, but their…
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Bias Can Anything Really Stop the Science Spin Snowball?Read more
With each set of hands study results pass through, there is a chance for another layer of spin to be…
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Bias Should We Trust Meta-Analyses with Meta-Conflicts of Interest?Read more
There are a couple of angles to look at researcher conflict of interest from. One is that a conflict could distort…
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Bias A Classic Case of Science “He Said”, “She Said”: How Psychologists Trying to Prevent PTSD Got ControversialRead more
Natural disasters have a lot in common with other major traumas, like life-threatening accidents and mass shootings – especially…
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Bias “True Patient Advocates Must Be Students of Evidence-Based Medicine”: An Impatient RebuttalRead more
Here’s the thing. If you’re a doctor who is a fervent advocate for a professional school of thought, and you feel…